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Ko te Topicastat he painga aukati whakataetae ki te xanthine oxidoreductase, na reira ka aukati i te hanga waikawa uric.Karekau he awenga aukati ki etahi atu whaamu kaitakawaenga purine pyrimidine, engari maataki te aukati i te awenga pukapuka matū ki te xanthine oxidoreductase.Ko te Topicastat he nui te aukati i runga i te XOR kua oxidized me te whakaheke, no reira ka kaha ake te kaha me te roa o tana paanga o te whakaheke i te waikawa uric, na reira ka taea te whakamahi i tenei hua mo te maimoatanga o te hyperuricemia tawhito i roto i te kauti.