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Ko te Topicastat he painga aukati whakataetae ki te xanthine oxidoreductase, na reira ka aukati i te hanga waikawa uric. Karekau he awenga aukati ki etahi atu whaamu whakakoi i te pyrimidine purine, engari ka aukati i te awenga o te Chemicalbook ki te xanthine oxidoreductase. Ko te Topicastat he painga aukati nui ki runga i te XOR oxidized me te whakaheke, no reira he kaha ake te kaha me te roa o te hua o te whakaheke i te waikawa uric, na reira ka taea te whakamahi i tenei hua mo te maimoatanga o te hyperuricemia tawhito i roto i te kauti.